Key result
In patients with repaired tetralogy of Fallot, the coupling between right ventricular volume and septal strain was broken during compensation, with the highest adverse effect on left ventricular deformation seen in those with right ventricular heart failure.
Why the study?
Patients with repaired tetralogy of Fallot face heightened risk of deteriorating cardiac function, and quantitative cardiac MRI techniques provide an opportunity to explore the mechanisms of cardiac deterioration.
Observational (n=152)
In patients with repaired tetralogy of Fallot, the adverse effect of right ventricular deformation on left ventricular deformation is highest after the onset of right ventricular heart failure.
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RV-LV strain coupling in rTOF RV failure supports biventricular monitoring; extends interdependence data but leaves therapeutic impact open.
Li et al. (2023) conducted an observational in Repaired tetralogy of Fallot with or without right ventricular heart failure (n=152). Right ventricular heart failure vs. Healthy controls and rTOF patients with preserved RV function was evaluated on Right-left ventricular interdependence (RV, LV, and septal strain). In patients with repaired tetralogy of Fallot, the coupling between right ventricular volume and septal strain was broken during compensation, with the highest adverse effect on left ventricular deformation seen in those with right ventricular heart failure.
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