June 16, 2018Nucleic Acids ResearchOpen Access

MBNL splicing activity depends on RNA binding site structural context

Q: What is the clinical evidence from this study?

Study design: Other. Intervention: RNA structural determinants. Primary outcome: MBNL-dependent alternative splicing activity.

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Key result

The structure of targeted RNAs is a prevalent component of the mechanism of alternative splicing regulation by MBNL proteins, with binding not entirely correlating with splicing efficiency.

Authors

KTKatarzyna TaylorAdam Mickiewicz University in Poznań ŁSŁukasz J. SznajderUniversity of Nevada, Las Vegas PCPiotr CywoniukAdam Mickiewicz University in Poznań

Discussion

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Implication

RNA structural rules govern MBNL splicing; leaves open cardiac impacts in myotonic dystrophy.

PICO

Exposure / Comparator

RNA structural determinants

Primary Outcome

MBNL-dependent alternative splicing activity

Cite This Study

Taylor et al. (2018) studied this question. RNA structural determinants was evaluated on MBNL-dependent alternative splicing activity. The structure of targeted RNAs is a prevalent component of the mechanism of alternative splicing regulation by MBNL proteins, with binding not entirely correlating with splicing efficiency.

synapsesocial.com/papers/6a9ccef5f4d73a8d78598f64 https://doi.org/10.1093/nar/gky565

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MBNL splicing activity depends on RNA binding site structural context

Discussion

Member takes

Implication

PICO

Cite This Study

MBNL splicing activity depends on RNA binding site structural context

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Also Consider