Key result
Bupivacaine inhibits mitochondrial state III respiration when acylcarnitines are the available substrate, with an IC50 of 0.78 mM for palmitoylcarnitine and 0.37 mM for acetylcarnitine.
Why the study?
Does bupivacaine inhibit carnitine metabolism in rat cardiac mitochondria?
Population
Rat cardiac interfibrillar mitochondria
Design
Preclinical
Authors
Loading...
Bupivacaine may impair rat cardiac mitochondrial respiration via acylcarnitines; leaves open relevance to human cardiotoxicity.
Does bupivacaine inhibit carnitine metabolism in rat cardiac mitochondria?
Bupivacaine inhibits mitochondrial state III respiration when acylcarnitines are the substrate, suggesting that inhibition of carnitine-acylcarnitine translocase may contribute to its cardiotoxic profile.
Weinberg et al. (2000) studied Rat cardiac interfibrillar mitochondria. Bupivacaine was evaluated on State III respiration (oxygen consumption). Bupivacaine inhibits mitochondrial state III respiration when acylcarnitines are the available substrate, with an IC50 of 0.78 mM for palmitoylcarnitine and 0.37 mM for acetylcarnitine.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: