Key result
Children with cystic fibrosis exhibited subclinical left ventricular dysfunction compared to healthy controls, including increased myocardial performance indexes and reduced segmental strain (P < .05).
Why the study?
Cystic fibrosis can cause left ventricular dysfunction, which may be detected at an early stage using tissue Doppler echocardiographic imaging and two-dimensional speckle tracking echocardiography.
Do tissue Doppler and speckle tracking echocardiography detect subclinical left ventricular dysfunction in children with cystic fibrosis compared to healthy controls?
Cohort (n=71)
Do tissue Doppler and speckle tracking echocardiography detect subclinical left ventricular dysfunction in children with cystic fibrosis compared to healthy controls?
Answers are grounded in this paper and cite their sources.
Tissue Doppler and speckle tracking echocardiography can detect subclinical left ventricular dysfunction in children with cystic fibrosis who have normal conventional echocardiographic findings.
BACKGROUND: Cystic fibrosis may lead to left ventricular (LV) dysfunction. This dysfunction can be documented by methods such as tissue Doppler echocardiographic (TDI) imaging and two-dimensional speckle tracking echocardiography (STE) in early stage. STUDY DESIGN: This was prospective cohort study. METHODS: A total of 34 patients diagnosed with cystic fibrosis (mean age and SD 9.9 ± 4.9 years) and 37 healthy control subjects with a comparable gender and age distribution (mean age 9.8 ± 4.3) were studied. The results for the two groups were compared along with the results of published reports. RESULTS: No significant relationship was found between the groups in terms of systolic and diastolic measurements of the interventricular septum and posterior left ventricular wall, and ejection fraction (P > .05). Myocardial performance indexes of left ventricular free wall and interventricular septum increased in the patient group compared with the controls (P < .05). As measured by STE, seven segments in the LV myocardial longitudinal strain and three segments in the LV myocardial circumferential strain showed significant reductions in patients with cystic fibrosis compared with controls (P < .05). The longitudinal global, circumferential global, and total global strain values had no significant difference between the groups (P > .05). Longitudinal strain rates and circumferential strain rates were both lower in five segments in the patient group (P < .05). CONCLUSIONS: Tissue Doppler echocardiographic imaging and STE may help identifying subclinical LV dysfunction in cystic fibrosis patients with unremarkable conventional echocardiography. They may be considered for the routine follow-up of cystic fibrosis patients.
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Kızılca et al. (2020) conducted a cohort in cystic fibrosis (n=71). Cystic fibrosis vs. Healthy control subjects was evaluated on Myocardial performance indexes and segmental strain (p=<.05). Children with cystic fibrosis exhibited subclinical left ventricular dysfunction compared to healthy controls, including increased myocardial performance indexes and reduced segmental strain (P < .05).
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