Key result
Childhood cystic fibrosis is linked to reduced LV longitudinal and circumferential strain versus healthy controls.
Why the study?
Cystic fibrosis may lead to left ventricular dysfunction, which can potentially be documented in early stages by tissue Doppler imaging and two-dimensional speckle tracking echocardiography.
Does tissue doppler and speckle tracking echocardiography detect subclinical left ventricular dysfunction in children with cystic fibrosis compared to healthy controls?
Case-Control (n=71)
Does tissue doppler and speckle tracking echocardiography detect subclinical left ventricular dysfunction in children with cystic fibrosis compared to healthy controls?
Tissue doppler and speckle tracking echocardiography can identify subclinical left ventricular dysfunction in children with cystic fibrosis who have unremarkable conventional echocardiography.
Answers are grounded in this paper and cite their sources.
Speckle tracking may detect subclinical LV strain reductions in children with CF; hypothesis-generating and requires prospective validation before practice change.
Background: Cystic fibrosis may lead to left ventricular dysfunction. This dysfunction can be documented by methods such as tissue doppler echocardiographic imaging and two-dimensional speckle tracking echocardiography in early stage. Patients and Methods: A total of 34 patients diagnosed with cystic fibrosis (mean age and SD 9.9±4.9 years) and 37 healthy control subjects with a comparable gender and age distribution (mean age 9.8±4.3) were studied. The results for the two groups were compared along with the results of published reports. Result: Control group had higher diastolic and systolic dimentions compared to the patient group in M-mode measurements of left ventricle by conventional echocardiography (p <0.05). There was no significant relationship between the groups in terms of the dimensions of systolic and diastolic measurements of interventricular septum and posterior wall of left ventricle, and ejection fraction. Pulmonary artery systolic pressure was significantly higher in the patient group (p<0.001). Myocardial performance indices of left ventricle free wall and interventricular septum were increased in the patient group compared to the control group (p<0.05). ). As measured by speckle tracking echocardiography, 7 segments in left ventricular myocardial longitudinal strain and 3 segments in left ventricular myocardial circumferential strain showed significant reductions in patients with cystic fibrosis compared to controls (p <0.05). Conclusions: Tissue doppler echocardiographic imaging and speckle tracking echocardiography may help identifying subclinical left ventricular dysfunction in cystic fibrosis patients with unremarkable conventional echocardiography. Its may be considered for the routine follow-up of cystic fibrosis patients.
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Kızılca et al. (2020) conducted a case-control in Cystic fibrosis (n=71). Cystic fibrosis vs. Healthy controls was evaluated on Left ventricular myocardial longitudinal and circumferential strain (p=<0.05). Children with cystic fibrosis showed significant reductions in 7 segments of left ventricular longitudinal strain and 3 segments of circumferential strain compared to healthy controls (p<0.05).
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