Key result
Failing spontaneously hypertensive rats exhibited enhanced myocardial cell death and a 7-fold diminished expression of LIFR (p<0.01) compared to non-failing rats, conferring resistance to CT-1.
Population
Adult spontaneously hypertensive rats with left ventricular hypertrophy and aged SHR with overt heart…
Comparison
In vitro stimulation with recombinant… vs Non-failing SHR vs failing SHR; untreated…
Design
Preclinical
Authors
Loading...
LIFR loss may promote cardiomyocyte death in HF; hypothesis-generating for LIFR-targeted therapies pending human studies.
p-value: p=<0.01
Loss of LIF receptor in failing hearts abolishes the cytoprotective effects of cardiotrophin-1, suggesting a mechanism by which neurohumoral activation contributes to cardiomyocyte death in heart failure.
Varo et al. (2007) studied Heart failure and left ventricular hypertrophy. Overt heart failure (failing SHR) vs. Left ventricular hypertrophy (non-failing SHR) was evaluated on Myocardial cell death and LIFR expression (p=<0.01). Failing spontaneously hypertensive rats exhibited enhanced myocardial cell death and a 7-fold diminished expression of LIFR (p<0.01) compared to non-failing rats, conferring resistance to CT-1.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: