Key result
In failing human hearts, CT-1 mRNA and protein expression were increased by 142% and 68%, respectively, while gp130 receptor protein abundance was diminished by 34% compared with non-failing hearts.
Observational
p-value: p=<0.001
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CT-1 upregulation and gp130 reduction in failing hearts may reflect pathway dysregulation; leaves open therapeutic targeting pending prospective studies.
Zolk et al. (2002) conducted an observational in End-stage heart failure due to ischemic and dilated cardiomyopathy. End-stage heart failure vs. Non-failing donor hearts was evaluated on Left ventricular expression of CT-1 and its glycoprotein 130 (gp130)/leukemia inhibitory factor receptor complex (p=<0.001). In failing human hearts, CT-1 mRNA and protein expression were increased by 142% and 68%, respectively, while gp130 receptor protein abundance was diminished by 34% compared with non-failing hearts.
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