Key result
Moderate/severe mitral regurgitation was associated with significantly higher plasma Cardiotrophin-1 concentrations compared to no significant valvular lesion (90.5 vs 53.3 fmol/ml; P<0.03).
Why the study?
Is plasma Cardiotrophin-1 elevated in patients with significant valvular regurgitation and normal left ventricular systolic function?
Cross-Sectional (n=78)
Is plasma Cardiotrophin-1 elevated in patients with significant valvular regurgitation and normal left ventricular systolic function?
Absolute Event Rate: 90.5% vs 53.3%
p-value: p=<0.03
Plasma Cardiotrophin-1 is elevated in patients with moderate/severe mitral regurgitation despite normal LV systolic function, suggesting its potential as a biochemical marker for monitoring disease progression.
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Hypothesis-generating for CT-1 in MR with preserved EF; does not support practice change pending longitudinal data.
Talwar et al. (2000) conducted a cross-sectional in Valvular regurgitation (n=78). Moderate/severe mitral regurgitation vs. No significant valvular lesion was evaluated on Plasma Cardiotrophin-1 (CT-1) concentration (fmol/ml) (p=<0.03). Moderate/severe mitral regurgitation was associated with significantly higher plasma Cardiotrophin-1 concentrations compared to no significant valvular lesion (90.5 vs 53.3 fmol/ml; P<0.03).
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