Key result
In patients with chronic heart failure and elevated BNP, high plasma CT-1 (>658 fmol/mL) was associated with increased mortality compared to lower CT-1 levels (HR 2.48; 95% CI 1.217-5.060; p=0.0124).
Cohort (n=125)
Hazard Ratio: 2.48 (95% CI 1.217–5.06)
p-value: p=0.0124
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High CT-1 may refine mortality risk stratification beyond BNP in chronic HF; leaves open incremental prognostic value in prospective validation.
Tsutamoto et al. (2007) conducted a cohort in Chronic heart failure (n=125). High plasma Cardiotrophin-1 (CT-1 >658 fmol/mL) and BNP >170 pg/mL vs. CT-1 <658 fmol/mL and BNP >170 pg/mL was evaluated on Mortality (HR 2.48, 95% CI 1.217-5.060, p=0.0124). In patients with chronic heart failure and elevated BNP, high plasma CT-1 (>658 fmol/mL) was associated with increased mortality compared to lower CT-1 levels (HR 2.48; 95% CI 1.217-5.060; p=0.0124).