June 1, 1999Journal of Hypertension
A heart-specific increase in cardiotrophin-1 gene expression precedes the establishment of ventricular hypertrophy in genetically hypertensive rats
Key result
Spontaneously hypertensive rats express elevated cardiotrophin-1 mRNA before overt ventricular hypertrophy.
Why the study?
Does cardiotrophin-1 gene expression correlate with the development of ventricular hypertrophy in genetically hypertensive rats?
Population
Spontaneously hypertensive rats/Izm stroke-prone and Wistar-Kyoto/Izm rats evaluated at neonate, 4, 12, and…
Comparison
Long-term treatment with lisinopril vs Wistar-Kyoto/Izm normotensive control rats, and…
Design
Preclinical
Follow-up
Up to 20 weeks of age
Authors
Discussion
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Implication
Early CT-1 expression in hypertensive rats warrants no clinical action; leaves open its biomarker role pending mechanistic studies.
Structured PICO
Does cardiotrophin-1 gene expression correlate with the development of ventricular hypertrophy in genetically hypertensive rats?
P
Population
Spontaneously hypertensive rats and normotensive control rats evaluated from neonate to 20 weeks of age to assess cardiotrophin-1 mRNA levels.
E
Exposure
Long-term treatment with lisinopril (in a subset of rats)
C
Comparator
Wistar-Kyoto/Izm (WKY/Izm) normotensive control rats, and untreated SHRSP/Izm rats
O
Outcome
Level of cardiotrophin-1 mRNA in the ventricle measured by Northern blot analysissurrogate
Cardiotrophin-1 mRNA expression increases early in genetically hypertensive rats but does not appear to play a mechanistic role in the development or maintenance of left ventricular hypertrophy.
Cite This Study
Ishikawa et al. (1999) studied ventricular hypertrophy associated with hypertension. Spontaneously hypertensive rats/Izm stroke-prone (SHRSP/Izm) vs. Wistar-Kyoto/Izm (WKY/Izm) rats was evaluated on cardiotrophin-1 mRNA level in the ventricle. Cardiotrophin-1 mRNA expression was significantly augmented in 4-week-old spontaneously hypertensive rats compared to controls, preceding overt ventricular hypertrophy.