What question did this study set out to answer?

To examine alterations in myocardial energy metabolism and assess the therapeutic efficacy of the dual PPARα/γ agonist TZD18 in rats with heart failure following myocardial infarction.

December 1, 2017

Dual PPARα/γ ligand TZD18 improves myocardial metabolic remodeling after myocardial infarction in rats.

Q: What is the clinical evidence from this study?

Study design: Other. Population: Heart failure after myocardial infarction. Intervention: TZD18 vs. Myocardial infarction group (no intervention) and sham surgery group. Primary outcome: Myocardial energy metabolism and ventricular remodeling indexes.

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Key result

TZD18 improved myocardial energy metabolism, mitochondrial respiratory activity, and ventricular remodeling in rats with heart failure after myocardial infarction.

Why the study?

Does TZD18 improve myocardial energy metabolism and ventricular remodeling in rats with heart failure after myocardial infarction?

Population

Rats with heart failure after myocardial infarction

Comparison

TZD18 (PPARα/γ dual agonist) vs Myocardial infarction group and sham surgery group

Design

Preclinical, randomly divided

Follow-up

8 weeks

Authors

LZLiu Zr YXYJ Xue XCX Chen

Discussion

Member takes

Implication

Hypothesis-generating in post-MI rat HF; leaves open clinical translation of dual PPAR agonism.

Key Points

To examine alterations in myocardial energy metabolism and assess the therapeutic efficacy of the dual PPARα/γ agonist TZD18 in rats with heart failure following myocardial infarction.
Rats with left anterior descending coronary artery ligation were randomly divided into a myocardial infarction group, a TZD18 intervention group, and a sham surgery control group.
Hemodynamic blood flow parameters and ventricular remodeling indexes were evaluated after an 8-week intervention period.
Myocardial tissue was analyzed using RT-PCR for PPARα/γ and α/β-MHC expression, high-performance liquid chromatography for mitochondrial adenosine, an oxygen consumption meter for mitochondrial respiration, and a tritium-labeled ADP assay for adenine nucleotide translocase activity.
Myocardial infarction significantly reduced PPARα/γ mRNA, the α/β-MHC ratio, high-energy phosphate content, mitochondrial respiration, and adenine nucleotide translocase transport, while significantly elevating the left ventricular weight-to-body weight ratio and impairing hemodynamics.
TZD18 intervention significantly increased PPARα/γ expression, up-regulated the α/β-MHC ratio, improved mitochondrial respiration and adenine nucleotide translocase transport, restored high-energy phosphate levels, and improved ventricular remodeling indexes.

Structured PICO

Does TZD18 improve myocardial energy metabolism and ventricular remodeling in rats with heart failure after myocardial infarction?

Population

Rats with heart failure after myocardial infarction, followed for 8 weeks.

Intervention

TZD18 (PPARα/γ dual agonist)

Comparator

Myocardial infarction group (no intervention) and sham surgery group

Outcome

Changes in myocardial energy metabolism (PPARα/γ mRNA, α/β-MHC mRNA, mitochondrial oxidative respiration activity, adenosine content, ANT transport activity) and ventricular remodeling indexes at 8 weekssurrogate

In a rat model of post-MI heart failure, the dual PPARα/γ agonist TZD18 improved myocardial energy metabolism and ventricular remodeling.

Cite This Study

Zr et al. (2017) studied Heart failure after myocardial infarction. TZD18 vs. Myocardial infarction group (no intervention) and sham surgery group was evaluated on Myocardial energy metabolism and ventricular remodeling indexes. TZD18 improved myocardial energy metabolism, mitochondrial respiratory activity, and ventricular remodeling in rats with heart failure after myocardial infarction.

synapsesocial.com/papers/6a9cf4358f152f04b0b7aa46 https://doi.org/10.26355/eurrev_201712_14023

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Dual PPARα/γ ligand TZD18 improves myocardial metabolic remodeling after myocardial infarction in rats.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Dual PPARα/γ ligand TZD18 improves myocardial metabolic remodeling after myocardial infarction in rats.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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