Key result
Experimental aortic insufficiency increased mean coronary blood flow with a shift to systolic flow in mild/moderate cases, but decreased flow with prominent backward diastolic flow in severe cases.
Why the study?
How does experimental aortic insufficiency alter phasic coronary flow patterns and systemic hemodynamics in dogs?
How does experimental aortic insufficiency alter phasic coronary flow patterns and systemic hemodynamics in dogs?
Severe aortic insufficiency in a canine model leads to decreased mean coronary blood flow and prominent backward coronary flow during diastole, offering a hemodynamic explanation for angina pectoris in this condition.
Answers are grounded in this paper and cite their sources.
Offers hemodynamic basis for angina in severe aortic insufficiency; leaves open translation of phasic flow changes to humans.
Systemic and coronary hemodynamic changes, especially phasic coronary flow pattern changes, were studied in experimental aortic insufficiency dogs. Aortic insufficiency severe enough to lower the mean aortic pressure resulted in an increase in aortic total flow and a decrease in aortic foward flow. Aortic pulse pressure always widened while no changes of systolic aortic pressure occurred. The mean coronary blood flow was increased significantly above control condition with the shift of normal diastolic flow to systole in mild and moderate cases, but was decreased in severe cases showing prominent backward coronary flow during diastole. The phasic coronary flow pattern changes had the close correlationship to the aortic pressure and the aortic regurgitant flow in the experimental aortic insufficiency. The mechanism of angina pectoris in aortic insufficiency was discussed from the standpoint of the phasic coronary flow.
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Tetsuo Mizutani (1973) studied Experimental aortic insufficiency. Experimental aortic insufficiency vs. Control condition was evaluated on Systemic and coronary hemodynamic changes, especially phasic coronary flow pattern changes. Experimental aortic insufficiency increased mean coronary blood flow with a shift to systolic flow in mild/moderate cases, but decreased flow with prominent backward diastolic flow in severe cases.
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