Key result
CRT-D with LVEF improvement >35% was associated with a significantly lower risk of receiving a first appropriate therapy compared to ICD (adjusted HR 0.24; 95% CI 0.07-0.83; P=0.025).
Why the study?
Does CRT-D reduce the risk of first appropriate therapy compared to ICD in patients with left ventricular dysfunction?
Population
175 consecutive patients with reduced LVEF treated with an ICD or CRT-D for primary or secondary prevention.
Comparison
Cardiac resynchronization therapy-defibrillator vs Implantable cardioverter-defibrillator (ICD)
Design
Cohort
Follow-up
Mean 2.5 ±1.5 years
Authors
Loading...
Should not yet change device selection; leaves open whether CRT-D reduces therapies versus ICD after LVEF recovery.
Cohort (n=175)
Does CRT-D reduce the risk of first appropriate therapy compared to ICD in patients with left ventricular dysfunction?
Hazard Ratio: 0.24 (95% CI 0.07–0.83)
p-value: p=0.025
CRT-D is associated with a reduced risk of appropriate device therapies compared to ICD in patients with left ventricular dysfunction, driven by improvements in LVEF.
Galve et al. (2018) conducted a cohort in Left ventricular dysfunction (n=175). CRT-D vs. ICD was evaluated on First appropriate therapy (adjusted HR 0.24, 95% CI 0.07-0.83, p=0.025). CRT-D with LVEF improvement >35% was associated with a significantly lower risk of receiving a first appropriate therapy compared to ICD (adjusted HR 0.24; 95% CI 0.07-0.83; P=0.025).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: