Key result
Elevated Glycemia Risk Index was independently associated with a significantly increased risk of carotid intima-media thickening in patients with type 2 diabetes (OR 7.226).
Why the study?
To evaluate the association between the Glycemic Risk Index and carotid intima-media thickness in patients with type 2 diabetes mellitus for early vascular risk assessment.
Does the Glycemic Risk Index (GRI) correlate with carotid intima-media thickness (CIMT) in previously untreated patients with type 2 diabetes?
Observational (n=450)
No
Does the Glycemic Risk Index (GRI) correlate with carotid intima-media thickness (CIMT) in previously untreated patients with type 2 diabetes?
The Glycemic Risk Index derived from continuous glucose monitoring is a strong independent predictor of carotid intima-media thickness in untreated type 2 diabetes, offering a potential tool for early cardiovascular risk stratification.
Objective: To investigate the association between the Glycemic Risk Index (GRI) and carotid intima-media thickness (CIMT) in type 2 diabetes mellitus (T2DM) patients and evaluate the clinical utility of GRI for early vascular risk assessment. Methods: This retrospective study included 450 previously untreated patients with T2DM prior to hospitalization. We calculated GRI using CGM data and assessed CIMT with high-resolution ultrasound. Multiple linear and logistic regression analyses assessed the association between GRI and CIMT. Receiver operating characteristic (ROC) curve analyses evaluated GRI's predictive performance. Results: There was a significant positive correlation between GRI and CIMT (r = 0.42, P < 0.001). After adjusting for confounders, GRI remained an independent predictor of CIMT thickening (OR = 7.226, 95% CI: 5.597-8.856, P < 0.001). ROC analysis revealed that GRI alone predicted abnormal CIMT with an AUC of 0.869. Conclusion: GRI is a robust marker for predicting CIMT thickening in T2DM patients, providing a novel approach for cardiovascular risk stratification. This study underscores the potential of integrating GRI into routine diabetes management to improve vascular outcomes.
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Zhao et al. (2025) conducted an observational in Type 2 diabetes mellitus (n=450). Glycemia Risk Index (GRI) vs. Lowest GRI quartile was evaluated on Carotid intima-media thickness (CIMT) thickening (≥1.0 mm) (OR 7.226, 95% CI 5.597-8.856, p=<0.001). Elevated Glycemia Risk Index was independently associated with a significantly increased risk of carotid intima-media thickening in patients with type 2 diabetes (OR 7.226).
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