Key result
Mouse intracardiac ganglion neurons have a resting membrane potential of -47.9 mV and exhibit strong synaptic transmission that is blocked by N-type calcium channel and alpha3-containing nAChR antagonists.
Why the study?
The intrinsic cardiac nervous system enables local control of cardiac performance, but the electrophysiological characteristics and ganglionic transmission of adult mouse intrinsic cardiac ganglion neurons required investigation.
Population
Adult mouse intrinsic cardiac ganglion neurons in excised right atrial ganglion plexus preparations
Design
Ex vivo electrophysiological study
Authors
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Mouse data on intracardiac neurons warrant clinical caution; leaves open translational relevance of N-type and alpha3 nAChR blockade.
Murine intrinsic cardiac ganglion neurons exhibit specific passive and active electrical properties and robust synaptic transmission that regulate cardiac function.
Harper et al. (2021) studied Normal physiology (intracardiac ganglion neurons). Vagal nerve stimulation and pharmacological blockade vs. Baseline/Control conditions was evaluated on Electrical properties and synaptic transmission efficacy. Mouse intracardiac ganglion neurons have a resting membrane potential of -47.9 mV and exhibit strong synaptic transmission that is blocked by N-type calcium channel and alpha3-containing nAChR antagonists.
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