Key result
Assistance with a miniaturized rotary blood pump significantly unloaded the heart, demonstrated by a drop in dP/dt max from 1645 to 1113 mmHg/s (P = 0.0003).
Why the study?
Does a miniaturized implantable rotary blood pump in an atrial-aortic position restore hemodynamics in a sheep model of heart failure?
Does a miniaturized implantable rotary blood pump in an atrial-aortic position restore hemodynamics in a sheep model of heart failure?
Absolute Event Rate: 1113% vs 1645%
p-value: p=0.0003
A miniaturized rotary blood pump using atrial cannulation effectively unloads the left ventricle and restores hemodynamics in a sheep model of severe heart failure.
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Supports development of miniaturized atrial-aortic pumps for LV unloading; leaves open translation to human HF trials.
Bart Meyns (1998) studied Heart failure (n=6). Miniaturized implantable rotary blood pump (diagonal pump) vs. Baseline (pre-assist values) was evaluated on First derivative of the left ventricular pressure (dP/dt) max (p=0.0003). Assistance with a miniaturized rotary blood pump significantly unloaded the heart, demonstrated by a drop in dP/dt max from 1645 to 1113 mmHg/s (P = 0.0003).
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