Why the study?
Does ventricular cannulation via the left atrium and through the mitral valve improve left ventricular unloading compared to atrial cannulation in a healthy sheep model?
Does ventricular cannulation via the left atrium and through the mitral valve improve left ventricular unloading compared to atrial cannulation in a healthy sheep model?
Left ventricular assist with a rotary blood pump can provide sufficient unloading with atrial cannulation, supporting potentially less invasive implantation methods.
Answers are grounded in this paper and cite their sources.
Atrial cannulation may suffice for LV unloading with rotary pumps; leaves open translation to less invasive human implantation.
BACKGROUND: Ventricular assist devices are gaining ground in the therapeutic treatment of chronic heart failure. These devices are sometimes used as a bridge to recovery by unloading the left ventricle (LV) and restoring its function. It is therefore important to preserve the heart muscle and apply less invasive implantation methods. METHODS: In this study ventricular unloading was achieved in 7 healthy sheep with a rotary blood pump at different pump flow levels. Ventricular cannulation via the left atrium (LA) and through the mitral valve was compared to atrial cannulation. The unloading of the heart was assessed with LV pressure-volume loops, derived energetic parameters, and an estimate of LV wall stress. RESULTS: No significant difference between the cannulations was found for any flow or pressure. LA cannulation, however, resulted in significantly lower stroke volumes and stroke work for all pump flow levels. Irrespective of cannulation site, LV volumes and energetic parameters showed a significant decrease with increasing pump flow. CONCLUSION: LV assist with a rotary blood pump can provide sufficient unloading with atrial cannulation.
No takes yet. Share an insight, caveat, or question.
Vandenberghe et al. (2004) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: