Key result
Atrial electromechanical delay at the lateral mitral annulus was significantly prolonged in patients with severe (78 ± 13 ms) and mild-moderate psoriasis (69 ± 12 ms) compared to healthy controls (60 ± 6 ms, p=0.001).
Why the study?
Is atrial electromechanical delay prolonged in patients with psoriasis compared to healthy controls?
Cross-Sectional (n=60)
No
Is atrial electromechanical delay prolonged in patients with psoriasis compared to healthy controls?
p-value: p=0.001
Atrial electromechanical delay is prolonged in patients with psoriasis and correlates with disease severity, suggesting a potential mechanism for increased atrial fibrillation risk in this population.
Prolonged atrial electromechanical delay may signal higher AF risk in psoriasis; hypothesis-generating and should not yet change practice.
OBJECTIVE: In this study, we aimed to investigate atrial electromechanical delay (EMD) in patients with psoriasis. SUBJECTS AND METHODS: A total of 43 patients with psoriasis (26 mild-moderate, 17 severe) and 17 healthy control subjects were enrolled. Patients with psoriasis were divided into two groups: the mild-moderate group and the severe group according to their psoriasis area severity index (PASI) scores. Atrial EMD was measured from the lateral mitral annulus and called 'PA lateral', from the septal mitral annulus, called 'PA septal', and from the right ventricle tricuspid annulus, called 'PA tricuspid'. Atrial EMD was defined as the time interval from the onset of atrial electrical activity (P wave on surface ECG) to the beginning of mechanical atrial contraction (late diastolic A wave). All three groups were compared with each other, and correlation analysis was performed to investigate the relationship between the PASI score and interatrial EMD. RESULTS: PA lateral was significantly higher in both the mild-moderate psoriasis group and the severe psoriasis group compared to controls (69 ± 12 and 78 ± 13 vs. 60 ± 6 ms; p = 0.001). Also, PA septal (63 ± 11 vs. 53 ± 6 ms; p = 0.005, post hoc analysis) and PA tricuspid (49 ± 7 vs. 41 ± 5 ms; p = 0.009, post hoc analysis) were significantly higher in the severe psoriasis group than in the control group. Correlation analysis revealed that the PASI score was well correlated with PA lateral (r = 0.520, p < 0.001), PA septum (r = 0.460, p = 0.002), interatrial EMD (r = 0.371, p = 0.014) and intra-atrial EMD (r = 0.393, p = 0.009). CONCLUSION: Atrial EMD was prolonged in patients with psoriasis. The measurement of atrial EMD might be used to determine the risk of development of AF in patients with psoriasis.
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Çalapkorur et al. (2014) conducted a cross-sectional in Psoriasis (n=60). Psoriasis vs. Healthy controls was evaluated on Atrial electromechanical delay at the lateral mitral annulus (PA lateral) (p=0.001). Atrial electromechanical delay at the lateral mitral annulus was significantly prolonged in patients with severe (78 ± 13 ms) and mild-moderate psoriasis (69 ± 12 ms) compared to healthy controls (60 ± 6 ms, p=0.001).
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