Key result
In patients with mitral valve disease, the anaerobic fraction of glycolysis (LD3%) increased with myocardial derangement (r=0.72), while volume load did not affect oxidative capacity.
Population
18 patients undergoing open-heart surgery for mitral valve disease, including a sub-group of 12 patients…
Design
Cross-sectional
Authors
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LD3% association with derangement in mitral valve disease is hypothesis-generating; leaves open volume load effects on myocardial metabolism.
Observational (n=18)
In patients with mitral valve disease, volume load appears to increase the anaerobic fraction of glycolysis without affecting oxidative capacity.
Sylvén et al. (1989) conducted an observational in Mitral valve disease (n=18). Myocardial derangement and volume load was evaluated on Metabolic adaptations in papillary muscle (enzymes of oxidative metabolism and glycolysis). In patients with mitral valve disease, the anaerobic fraction of glycolysis (LD3%) increased with myocardial derangement (r=0.72), while volume load did not affect oxidative capacity.
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