What question did this study set out to answer?

To compare the activities of major metabolic enzymes between human myocardial muscle and skeletal muscle from physically trained and untrained individuals.

October 1, 1986Clinical Physiology

Activities of key enzymes in the energy metabolism of human myocardial and skeletal muscle

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Population

Physically trained and untrained men and patients subjected to open heart surgery because of valve disease

Design

Cross-sectional

Authors

EJEva JanssonKarolinska University Hospital CSChrister SylvénCardiac Imaging

Discussion

Member takes

Implication

Informs metabolic phenotyping in cardiomyopathies vs myopathies; leaves open translation to ischemia tolerance or targeted therapies pending outcomes data.

Key Points

To compare the activities of major metabolic enzymes between human myocardial muscle and skeletal muscle from physically trained and untrained individuals.
Obtained skeletal muscle biopsies from physically trained and untrained men.
Collected myocardial biopsies from patients undergoing open-heart surgery for valve disease.
Measured the enzymatic activities of total CK, CK-MB, total LD, LD1, PFK, ASAT, and CS across all muscle samples.
Citrate synthase, aspartate aminotransferase, and LD1 activities were higher in trained than in untrained skeletal muscle, and reached the highest activities in myocardial tissue.
Myocardial total creatine kinase activity was approximately one-third that of skeletal muscle, whereas myocardial CK-MB activity matched that of trained skeletal muscle.
Phosphofructokinase and total lactate dehydrogenase activities remained of similar magnitude across muscle types, demonstrating a 2- to 3-fold higher oxidative capacity in myocardial muscle alongside equivalent glycolytic capacity.

Structured PICO

Population

Physically trained and untrained men (skeletal muscle biopsies) and patients subjected to open heart surgery because of valve disease (myocardial biopsies)

Comparator

Comparison between trained skeletal muscle, untrained skeletal muscle, and myocardial muscle

Outcome

Activities of key enzymes in energy metabolism (CK, CK-MB, LD, LD1, PFK, ASAT, CS)surrogate

Myocardial muscle has a significantly higher oxidative capacity compared to skeletal muscle, while maintaining a similar glycolytic capacity.

Cite This Study

Jansson et al. (1986) studied this question.

synapsesocial.com/papers/6a8a9532c2053d0432d43bb5 https://doi.org/10.1111/j.1475-097x.1986.tb00077.x

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Implication

Informs metabolic phenotyping in cardiomyopathies vs myopathies; leaves open translation to ischemia tolerance or targeted therapies pending outcomes data.

Activities of key enzymes in the energy metabolism of human myocardial and skeletal muscle

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Activities of key enzymes in the energy metabolism of human myocardial and skeletal muscle

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider