Key result
Published and unpublished consensus guidelines on anticardiolipin and lupus anticoagulant testing aim to decrease interlaboratory and intermethod assay variation.
This review highlights consensus guidelines aimed at standardizing anticardiolipin and lupus anticoagulant testing to improve diagnostic value by reducing assay variation.
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Standardization of anticardiolipin and lupus anticoagulant assays may improve diagnostic reliability; leaves open the need for outcome studies to confirm clinical impact.
Interlaboratory and intermethod variation in commercial and in-house tests used for the measurement of anticardiolipin antibodies (aCL) and lupus anticoagulant (LA) limit the diagnostic value of the results from these tests. This short review summarizes published and unpublished guidelines (some developed using consensus procedures) on aCL and LA testing that are aimed at decreasing assay variation. KEYWORDS Cardiolipin - consensus guidelines - lupus anticoagulant - recommendation - standardization
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Wong et al. (2005) conducted a review in Anticardiolipin and lupus anticoagulant testing. Consensus guidelines for anticardiolipin and lupus anticoagulant testing was evaluated. Published and unpublished consensus guidelines on anticardiolipin and lupus anticoagulant testing aim to decrease interlaboratory and intermethod assay variation.
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