Key result
Administration of angiotensin II, DOCA, ACTH, or spironolactone had no significant effects on arterial blood pressure, glomerular filtration rate, urine flow, or electrolyte excretion in spiny dogfish sharks.
Why the study?
Do angiotensin II, DOCA, ACTH, or spironolactone affect renal function in spiny dogfish sharks?
Do angiotensin II, DOCA, ACTH, or spironolactone affect renal function in spiny dogfish sharks?
The dogfish kidney does not appear to be a target organ for angiotensin II, DOCA, ACTH, or spironolactone, unlike in other animals.
Caution against extrapolating mammalian RAAS effects to sharks; extends comparative physiology while leaving open evolutionary mechanisms.
Angiotensin II was infused intravenously in spiny dogfish sharks (Squalus acanthias). There were no significant effects on arterial blood pressure, glomerular filtration rate, urine flow, or Na excretion either in comparison with pre- and postinfusion values or in comparison with values measured in a control group of fish given elasmobranch saline intravenously. In other dogfish, glomerular filtration rate, urine flow, and Na and K excretory rates were measured for 3 days following implantation of desoxycorticosterone (DOCA), adrenocorticotropin (ACTH), or spironolactone; a control group was given no drug. There were no significant differences between these four groups of fish with respect to any of the measured parameters. These results suggest that the dogfish kidney is not a target organ for several substances known to affect renal function, either directly or indirectly, in other animals.
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Churchill et al. (1985) studied this question. Angiotensin II, DOCA, ACTH, or spironolactone vs. Elasmobranch saline or no drug was evaluated on Arterial blood pressure, glomerular filtration rate, urine flow, and Na/K excretion. Administration of angiotensin II, DOCA, ACTH, or spironolactone had no significant effects on arterial blood pressure, glomerular filtration rate, urine flow, or electrolyte excretion in spiny dogfish sharks.
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