5-HT dilates guinea-pig coronary arteries largely by releasing NO from the coronary endothelium, and saponin is an effective tool for revealing endothelium-dependent actions without impairing contractile function.
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Ellwood et al. (1996) studied this question. 5-hydroxytryptamine (5-HT) vs. Baseline was evaluated on Coronary flow and coronary effluent NO content (p=<0.05).
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