June 1, 1992Clinical Cardiology
Myocardial systolic function in systemic lupus erythematosus: A study based on radionuclide ventriculography
Key result
Among patients with systemic lupus erythematosus, resting LV systolic function was normal, but 3 of 8 patients (37.5%) who exercised had an abnormal ventriculographic response.
Why the study?
Does radionuclide ventriculography detect subclinical left ventricular dysfunction in patients with systemic lupus erythematosus?
Population
20 consecutive unselected patients with systemic lupus erythematosus
Design
Cross-sectional
Authors
Discussion
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Implication
Exercise radionuclide ventriculography may unmask subclinical LV dysfunction in SLE; leaves open need for prospective validation before clinical adoption.
Study Design
Type
Observational (n=20)
Structured PICO
Does radionuclide ventriculography detect subclinical left ventricular dysfunction in patients with systemic lupus erythematosus?
P
Population
20 consecutive unselected patients with systemic lupus erythematosus evaluated for left ventricular systolic function.
E
Exposure
Radionuclide ventriculography (resting and exercise)
O
Outcome
Left ventricular systolic function (ejection fraction and regional wall motion abnormalities)surrogate
Radionuclide ventriculography can unmask subclinical left ventricular dysfunction during exercise in patients with systemic lupus erythematosus who have normal resting ejection fractions.
Limitations
- Clinical significance of these abnormalities on long-term myocardial function and their possible reversibility with remission of the disease needs to be assessed in future studies.
Cite This Study
Bahl et al. (1992) conducted an observational in Systemic lupus erythematosus (n=20). Systemic lupus erythematosus was evaluated on Abnormal ventriculographic response to exercise. Among patients with systemic lupus erythematosus, resting LV systolic function was normal, but 3 of 8 patients (37.5%) who exercised had an abnormal ventriculographic response.