Key result
Right ventricular dysfunction was detected in 37% of non-advanced IPF patients and was associated with significantly higher mean pulmonary artery pressure at rest (26.0 vs 19.1 mmHg, p=0.001) and during exercise (51.3 vs 36.9 mmHg, p=0.002).
Why the study?
Little is known about the occurrence of pulmonary hypertension and subsequent right ventricular dysfunction in non-advanced idiopathic pulmonary fibrosis patients without hypoxemia at rest.
Is right ventricular dysfunction present in non-advanced IPF patients and is it associated with increased mean pulmonary artery pressure?
Population
27 non-advanced idiopathic pulmonary fibrosis patients without hypoxemia at rest
Comparison
Patients with right ventricular dysfunction vs those without dysfunction
Design
Cross-sectional prospective single-center study
Authors
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RV dysfunction occurs in 37% of non-advanced IPF without hypoxemia; leaves open whether speckle-tracking screening improves outcomes.
Cross-Sectional (n=27)
No
Is right ventricular dysfunction present in non-advanced IPF patients and is it associated with increased mean pulmonary artery pressure?
Absolute Event Rate: 26% vs 19.1%
p-value: p=0.001
Speckle-tracking echocardiography can detect early right ventricular dysfunction in over a third of non-advanced IPF patients, which correlates with significantly elevated pulmonary artery pressures.
Negreiros et al. (2020) conducted a cross-sectional in Non-severe idiopathic pulmonary fibrosis (n=27). Right ventricular dysfunction vs. Normal right ventricular function was evaluated on Mean pulmonary artery pressure (mPAP) at rest (p=0.001). Right ventricular dysfunction was detected in 37% of non-advanced IPF patients and was associated with significantly higher mean pulmonary artery pressure at rest (26.0 vs 19.1 mmHg, p=0.001) and during exercise (51.3 vs 36.9 mmHg, p=0.002).
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