Key result
Idiopathic pulmonary fibrosis is linked to early LV diastolic impairment and a reversed E/A ratio.
Why the study?
Do patients with idiopathic pulmonary fibrosis exhibit left ventricular diastolic dysfunction compared to healthy controls?
Population
44 individuals, comprising 22 patients with idiopathic pulmonary fibrosis exhibiting mild-to-moderate…
Comparison
Evaluation using conventional and tissue Doppler… vs Healthy individuals
Design
Case-control
Authors
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May warrant diastolic screening in IPF; leaves open causal links and outcome impact.
Case-Control (n=44)
Do patients with idiopathic pulmonary fibrosis exhibit left ventricular diastolic dysfunction compared to healthy controls?
Absolute Event Rate: 0.7% vs 1.5%
Patients with idiopathic pulmonary fibrosis and mild-to-moderate pulmonary arterial hypertension exhibit early impairment of left ventricular diastolic function, which can be detected by tissue Doppler echocardiography.
Papadopoulos et al. (2007) conducted a case-control in Idiopathic pulmonary fibrosis (n=44). Idiopathic pulmonary fibrosis vs. Healthy individuals was evaluated on Early diastolic peak filling velocity (E) / late diastolic peak filling velocity ratio. Idiopathic pulmonary fibrosis is associated with early impairment of left ventricular diastolic function, including a reversed E/A ratio (0.7 vs 1.5) compared to healthy controls.
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