Left Ventricular Dysfunction Induced by Nonsevere Idiopathic Pulmonary Arterial Hypertension: A Pressure–Volume Relationship Study

Mario Kašner; Dirk Westermann; Paul Steendijk; Stephan Dröse; Wolfgang Poller; Heinz‐Peter Schultheiss; Carsten Tschöpe

doi:10.1164/rccm.201110-1860oc

May 5, 2012American Journal of Respiratory and Critical Care MedicineOpen Access

Left Ventricular Dysfunction Induced by Nonsevere Idiopathic Pulmonary Arterial Hypertension: A Pressure–Volume Relationship Study

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Why the study?

Does nonsevere idiopathic pulmonary arterial hypertension impair left ventricular diastolic compliance through interventricular interaction?

Structured PICO

Does nonsevere idiopathic pulmonary arterial hypertension impair left ventricular diastolic compliance through interventricular interaction?

P

Population

29 subjects, including patients with mild idiopathic pulmonary arterial hypertension (IPAH, n=10), patients with isolated left ventricular diastolic dysfunction (DD, n=10), and control subjects without heart failure symptoms (n=9).

I

Intervention

Invasive pressure-volume (PV) loop analysis via conductance catheterization at rest, during atrial pacing (120 bpm), and during inferior vena cava occlusion.

C

Comparator

Patients with isolated LV diastolic dysfunction and control subjects without heart failure symptoms.

O

Outcome

Left ventricular function and interventricular interaction (stroke volume, cardiac output, LV end-diastolic volume, LV stiffness).surrogate

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Implication

Mild idiopathic pulmonary arterial hypertension impairs left ventricular diastolic compliance due to interventricular interaction, contributing to reduced cardiac performance during stress.

Abstract

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Cite This Study

Kašner et al. (2012) studied this question.

synapsesocial.com/papers/6a8d112c43002c5646906735 https://doi.org/10.1164/rccm.201110-1860oc

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Left Ventricular Dysfunction Induced by Nonsevere Idiopathic Pulmonary Arterial Hypertension: A Pressure–Volume Relationship Study

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Left Ventricular Dysfunction Induced by Nonsevere Idiopathic Pulmonary Arterial Hypertension: A Pressure–Volume Relationship Study

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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