Key result
Desflurane is an effective anesthetic for patients with myasthenia gravis, offering rapid emergence and intrinsic muscle relaxant properties that facilitate anesthesia management without neuromuscular blocking agents.
Desflurane is an effective anesthetic for patients with myasthenia gravis when managed without neuromuscular blocking agents due to its inherent muscle relaxant properties and rapid emergence.
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Desflurane may enable relaxant-free anesthesia with rapid recovery in MG; Level 5 evidence leaves open need for controlled trials before practice change.
デスフルランは血液/ガス分配係数が0.45と亜酸化窒素並みに小さく，麻酔の導入，覚醒が速やかである．また生体内代謝率が0.02％と低く，生体内で安定している．これらのことは，術後呼吸不全のリスクが大きい神経・筋疾患患者の麻酔管理において重要なポイントとなる．デスフルランは単独でも筋弛緩作用を持ち，筋弛緩薬の効果を増強することが知られているが，重症筋無力症（mg）患者ではその傾向はより強くなる．しかしmg患者に筋弛緩薬を使用せずに麻酔管理する場合に，覚醒が早く筋弛緩作用のあるデスフルランは，手術を安全に行うためには有効な麻酔薬である．
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Motomu Kobayashi (2016) conducted a review in Neuromuscular diseases, Myasthenia Gravis. Desflurane was evaluated. Desflurane is an effective anesthetic for patients with myasthenia gravis, offering rapid emergence and intrinsic muscle relaxant properties that facilitate anesthesia management without neuromuscular blocking agents.
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