Key result
Expression of the bovine viral diarrhea virus NS3 protein in mammalian cells induces apoptosis initiated by caspase-8 activation and subsequent cytochrome c release-dependent caspase-9 activation.
Population
Mammalian cell lines (A549tTA, Vero, Cf2Th, MDBK) cultured in vitro
Comparison
Expression of bovine viral diarrhea virus NS3 or… vs Mock infection, AdV expressing GFP only, or…
Design
Preclinical
Follow-up
up to 60 hours post-infection
Authors
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No direct clinical implications yet; leaves open NS3 as a target for BVDV pathogenesis and intervention studies.
The BVDV NS3 protein induces apoptosis in mammalian cells through a pathway initiated by caspase-8 activation and subsequent cytochrome c release-dependent caspase-9 activation.
St-Louis et al. (2005) studied Bovine viral diarrhea virus (BVDV) infection. BVDV NS3 and NS3Δ50 protein expression via adenoviral vectors vs. Mock infection or AdV-GFP was evaluated on Apoptosis induction and caspase activation. Expression of the bovine viral diarrhea virus NS3 protein in mammalian cells induces apoptosis initiated by caspase-8 activation and subsequent cytochrome c release-dependent caspase-9 activation.
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