Key result
Low-density lipoprotein enters the inner canine aortic wall directly from the lumen at a rate that is highest in the proximal aorta and decreases progressively down its length.
The study demonstrates a spatial gradient of LDL entry into the canine aortic wall, highest proximally, which mirrors the pattern of cholesterol accumulation in early experimental atherosclerosis.
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Hypothesis-generating in canine models; leaves open relevance to human aortic atherosclerosis patterns.
Duncan et al. (1963) studied this question. Low-density lipoprotein enters the inner canine aortic wall directly from the lumen at a rate that is highest in the proximal aorta and decreases progressively down its length.
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