Key result
Arterial cholesterol uptake lacks spatial dependence, with flux ~100-fold lower than predicted by diffusion models.
Why the study?
The mechanism by which wall shear rate influences transport of materials between blood and arterial wall is unclear, particularly whether transport is controlled by diffusion across a boundary layer.
Population
Dog common carotid artery perfused with serum containing 14 C-4-cholesterol
Comparison
Transport under varying wall shear rates and spatial positions
Design
Perfusion study with fluid mechanics resembling diffusion boundary layer model
Authors
Loading...
Shear-dependent arterial transport may involve boundary layer diffusion; leaves open mechanistic targets in atherosclerosis.
Robert M. Nerem (1973) studied this question. Perfusion with serum containing 14C-4-cholesterol linked with lipoprotein was evaluated on Spatial dependence of uptake of the label and flux. In 20 experiments on perfused dog common carotid arteries, there was no spatial dependence of 14C-4-cholesterol uptake, and flux was about 100 times lower than predicted by diffusion models.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: