Key result
Cholesterol movement into the canine aortic wall decreases ~83% from the proximal to terminal aorta.
The study demonstrates a gradient in the rate of cholesterol movement into the aortic wall of normal dogs, supporting the concept that cholesterol is carried by lipoproteins.
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Regional cholesterol influx gradient in healthy canine aortas is hypothesis-generating; leaves open relevance to human atherosclerosis.
Duncan et al. (1959) studied Normal dogs. Labeled cholesterol was evaluated on Rate of movement of cholesterol from serum into the inner layer of the aortic wall. In normal dogs, the rate of movement of labeled cholesterol into the aortic wall is greatest proximally and decreases progressively to about one sixth in the terminal aorta.
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