Key result
Ischaemia in the heart, skeletal muscle, and skin is followed by marked hyperaemia upon reperfusion of similar magnitude and duration in both control and capsaicin-pre-treated pigs.
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Post-ischemic hyperemia magnitude is preserved after capsaicin in pigs; leaves open sensory nerve contribution to human reperfusion responses.
In the present study we have tried to characterize and quantify the post‐occlusive hyperaemia in the pig heart, skeletal muscle and skin circulation. In addition, the possible involvement of caspaicin‐sensitive sensory nerves in the reactive hyperaemia was investigated. Reperfusion after total stop‐flow ischaemia for 1, 5 or 15 min elicited a marked hyperaemia in all vascular beds studied. The post‐occlusive hyperaemia after 5 min ischaemia was 512 ± 74 %, 328 ± 94 % and 444 ± 87 % in the heart, femoral artery and saphenous artery respectively. Also, in the skin the blood flow following 5 min ischaemia was increased fivefold. Furthermore, the duration of the hyperaemia after 5 min ischaemia was significantly (P < 0.01) longer in the heart (382 ± 32 s) than that in the femoral artery (192 ± 27 s), saphenous artery (182 ± 48 s) and skin (95 ± 14 s). Increasing the ischaemic time period prolonged the duration as well as elevated the peak increase of the hyperaemia. Capsaicin pre‐treatment significantly reduced (by about 70%) the tissue levels of calcitonin gene‐related peptide (CGRP)‐like immunoreactivity (‐LI), which is present in sensory nerves, but not neuropeptide Y‐LI, which is of sympathetic origin, in the left ventricle of the heart, quadriceps muscle and skin in the pig. However, there were no differences in the post‐occlusive hyperaemia in control and capsaicin‐pre‐treated pigs. Capsaicin administered intracutaneously caused a long‐lasting (about 20 min) increase in skin blood flow in the pig. This enhanced blood flow was completely abolished after systemic capsaicin pre‐treatment. It is concluded that ischaemia, especially in the heart but also in skeletal muscle and skin, is followed by a marked hyperaemia upon reperfusion of similar magnitude and duration in both control and capsaicin‐pre‐treated pigs. This argues against a primary involvement of peptides with vasodilatory activity released from sensory nerves in this reaction, although sensory nerve activation induced by capsaicin evoked an increase in local blood flow.,
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FRANCO‐CERECED et al. (1989) studied this question. Capsaicin pre-treatment vs. Control was evaluated on Post-occlusive hyperaemia after ischaemia. Ischaemia in the heart, skeletal muscle, and skin is followed by marked hyperaemia upon reperfusion of similar magnitude and duration in both control and capsaicin-pre-treated pigs.
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