Key result
A 30 micrograms/kg fentanyl bolus in preterm infants yielded an elimination half-life of 17.7 hours and stable systolic blood pressure, with a gradual increase in heart rate (P<0.05).
Why the study?
What are the pharmacokinetics and hemodynamic effects of a 30 mcg/kg fentanyl bolus in preterm infants during patent ductus arteriosus ligation?
What are the pharmacokinetics and hemodynamic effects of a 30 mcg/kg fentanyl bolus in preterm infants during patent ductus arteriosus ligation?
A 30 mcg/kg bolus of fentanyl provides stable hemodynamics during PDA ligation in preterm infants, though spontaneous movement and breathing may return despite unchanged plasma concentrations, likely due to redistribution.
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Stable hemodynamics observed with 30 mcg/kg fentanyl in preterm PDA ligation; leaves open optimal dosing pending larger pharmacokinetic studies.
Collins et al. (1985) studied Patent ductus arteriosus (n=9). Fentanyl was evaluated on Pharmacokinetics and hemodynamic effects. A 30 micrograms/kg fentanyl bolus in preterm infants yielded an elimination half-life of 17.7 hours and stable systolic blood pressure, with a gradual increase in heart rate (P<0.05).
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