Key result
AGTR1 A1166C and AGTR2 A1332G polymorphisms were not significantly associated with chronic kidney disease, end-stage renal disease, IgA nephropathy, or vesicoureteral reflux.
Why the study?
Are AGTR1 A1166C and AGTR2 A1332G polymorphisms associated with the development of renal diseases?
Meta-Analysis
Are AGTR1 A1166C and AGTR2 A1332G polymorphisms associated with the development of renal diseases?
AGTR1 A1166C and AGTR2 A1332G polymorphisms are not significantly associated with renal diseases and cannot be used as predictive markers.
No association found with CKD/ESRD/IgAN/VUR; leaves open larger studies in ethnic subgroups before ruling out predictive utility.
Renal failure has a complex phenotype resulting from an underlying kidney disease as well as environmental and genetic factors. In the present study we performed a systematic review and meta-analyses to evaluate the association of the A1166C polymorphism of Angiotensin II type 1 Receptor gene (AGTR1) with Chronic Kidney Disease (CKD), End Stage Renal Disease (ESRD), IgA Nephropathy (IgAN) and Vesicoureteral Reflux (VUR) as well as the association of A1332G polymorphism of Angiotensin II type 2 Receptor (AGTR2) gene with Vesicoureteral Reflux (VUR). We found that neither AGTR1 Α1166C, nor AGTR2 A1332G polymorphisms were significantly associated with any of the aforementioned renal diseases, suggesting that they cannot be used as predictive markers in either general or subgroup ethnic populations.
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Braliou et al. (2014) conducted a meta-analysis in Renal diseases (CKD, ESRD, IgAN, VUR). AGTR1 A1166C and AGTR2 A1332G polymorphisms was evaluated on Association with Chronic Kidney Disease (CKD), End Stage Renal Disease (ESRD), IgA Nephropathy (IgAN) and Vesicoureteral Reflux (VUR). AGTR1 A1166C and AGTR2 A1332G polymorphisms were not significantly associated with chronic kidney disease, end-stage renal disease, IgA nephropathy, or vesicoureteral reflux.
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