What question did this study set out to answer?

To determine whether motor current waveforms in continuous-flow centrifugal blood pumps can serve as a continuous, noninvasive index of native left ventricular pressure and cardiac function.

September 1, 2001Artificial Organs

Motor Current Waveforms as an Index for Evaluation of Native Cardiac Function During Left Ventricular Support with a Centrifugal Blood Pump

Q: What is the clinical evidence from this study?

Population: Ventricular assist device monitoring (n=5). Intervention: Motor current amplitude monitoring of a centrifugal blood pump. Primary outcome: Correlation between motor current and left ventricular pressure.

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Key result

Motor current amplitude of a centrifugal blood pump showed an excellent correlation with left ventricular pressure in both in vitro (r=0.77-0.99) and in vivo sheep models (r=0.70-0.94).

Why the study?

Does motor current amplitude monitoring correlate with left ventricular pressure in a centrifugal blood pump model?

Key Points

To determine whether motor current waveforms in continuous-flow centrifugal blood pumps can serve as a continuous, noninvasive index of native left ventricular pressure and cardiac function.
Tested a centrifugal blood pump in an in vitro mock loop across speeds of 1,300, 1,500, and 1,700 rpm while increasing left ventricular systolic pressure from 40 to 140 mm Hg in 20 mm Hg increments.
Created a left heart bypass model in N=5 sheep connecting the ventricular apex to the descending aorta, manipulating left ventricular pressure via dopamine at 1,500 and 1,700 rpm.
In vitro correlation coefficients between motor current and left ventricular pressure reached 0.77 at 1,300 rpm, 0.92 at 1,500 rpm, and 0.99 at 1,700 rpm.
In vivo correlations between motor current and left ventricular pressure ranged from 0.70 to 0.93 across 5 sheep at 1,500 rpm, and from 0.85 to 0.94 across 4 sheep at 1,700 rpm.
Motor current combined with pump flow exhibited an unstable correlation with left ventricular pressure in vivo, supporting direct motor current amplitude as the more reliable monitoring index.

Structured PICO

Does motor current amplitude monitoring correlate with left ventricular pressure in a centrifugal blood pump model?

Population

In vitro mock circulatory loop and in vivo experiments using 5 sheep to evaluate motor current waveforms during left ventricular support with a centrifugal blood pump.

Intervention

Monitoring of motor current amplitude of the centrifugal blood pump at fixed rpms (1,300, 1,500, and 1,700) while varying LV pressure (via dopamine in vivo).

Outcome

Correlation between motor current and left ventricular (LV) pressure.surrogate

Motor current amplitude from a centrifugal blood pump correlates well with left ventricular pressure, suggesting it could be a useful index for monitoring native cardiac function during VAD support.

Discussion

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Implication

May enable noninvasive LV pressure monitoring during centrifugal VAD support; leaves open human validation.

Cite This Study

Daiki Kikugawa (2001) studied Ventricular assist device monitoring (n=5). Motor current amplitude monitoring of a centrifugal blood pump was evaluated on Correlation between motor current and left ventricular pressure. Motor current amplitude of a centrifugal blood pump showed an excellent correlation with left ventricular pressure in both in vitro (r=0.77-0.99) and in vivo sheep models (r=0.70-0.94).

synapsesocial.com/papers/6a9e891abfc0e66ac2fba795 https://doi.org/10.1046/j.1525-1594.2001.06860.x

Topics

Mechanical circulatory support

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Motor Current Waveforms as an Index for Evaluation of Native Cardiac Function During Left Ventricular Support with a Centrifugal Blood Pump

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Motor Current Waveforms as an Index for Evaluation of Native Cardiac Function During Left Ventricular Support with a Centrifugal Blood Pump

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider