Key result
Sodium bicarbonate treats tricyclic antidepressant-induced arrhythmias by raising plasma pH, which increases protein binding of the drug and reduces its unbound fraction.
Why the study?
Does sodium bicarbonate resolve arrhythmias in tricyclic antidepressant overdosage?
Population
Puppies with amitriptyline-induced arrhythmias (preclinical model)
Design
Preclinical
Authors
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Animal data support pH-driven protein binding mechanism; leaves open human confirmation before practice change.
Does sodium bicarbonate resolve arrhythmias in tricyclic antidepressant overdosage?
Sodium bicarbonate exerts an antiarrhythmic effect in tricyclic antidepressant overdose by raising pH, which increases plasma protein binding and reduces the unbound fraction of the drug.
Brown et al. (1973) conducted a review in Tricyclic antidepressant-induced arrhythmias. Sodium bicarbonate was evaluated. Sodium bicarbonate treats tricyclic antidepressant-induced arrhythmias by raising plasma pH, which increases protein binding of the drug and reduces its unbound fraction.
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