Key result
Quercetin pretreatment significantly mitigated daunorubicin-induced decreases in mitochondrial glutathione peroxidase activity (76.5% vs 61.8% of control, p<0.01) in rats.
Why the study?
Does quercetin prevent daunorubicin-induced heart mitochondria changes in rats?
Population
40 Male Wistar rats, weighing 190-200 g
Comparison
Quercetin 100 mg/kg intragastrically given 60… vs Daunorubicin 15 mg/kg intraperitoneally alone…
Design
Preclinical, randomly divided into 4 groups
Follow-up
24 hours
Authors
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Hypothesis-generating for quercetin in anthracycline cardiotoxicity; leaves open translation to clinical use.
Does quercetin prevent daunorubicin-induced heart mitochondria changes in rats?
Absolute Event Rate: 76.5% vs 61.8%
p-value: p=<0.01
Quercetin pretreatment mitigates daunorubicin-induced acute cardiotoxicity in rats by preserving mitochondrial antioxidant enzyme activities and membrane integrity.
Guzy et al. (2003) studied Daunorubicin-induced cardiotoxicity (n=40). Quercetin vs. Daunorubicin alone was evaluated on Mitochondrial glutathione peroxidase (GPx) activity (% of control) (p=<0.01). Quercetin pretreatment significantly mitigated daunorubicin-induced decreases in mitochondrial glutathione peroxidase activity (76.5% vs 61.8% of control, p<0.01) in rats.
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