Key result
Hyperthermia-induced changes in central blood volume strongly correlated with changes in arterial plasma atrial natriuretic peptide (R=0.80, p<0.01), suggesting its utility as a surrogate marker.
Why the study?
Does plasma ANP reflect changes in central blood volume during hyperthermia in healthy humans?
Observational (n=10)
No
Does plasma ANP reflect changes in central blood volume during hyperthermia in healthy humans?
Plasma ANP may serve as a surrogate marker for acute changes in central blood volume during hyperthermia.
Hypothesis-generating in healthy volunteers; leaves open validation and clinical utility in patients.
BACKGROUND: Hyperthermia induces vasodilatation that reduces central blood volume (CBV), central venous pressure (CVP) and mean arterial pressure (MAP). Inhibition of atrial natriuretic peptide (ANP) could be a relevant homeostatic defense mechanism during hyperthermia with a decrease in CBV. The present study evaluated how changes in plasma ANP reflect the changes in CBV during hyperthermia. METHODS: ) and venous plasma ANP were determined by radioimmunoassay. RESULTS: and MAP or CVP. CONCLUSION: may be used as a surrogate marker of acute CBV changes.
No takes yet. Share an insight, caveat, or question.
Thomas W. Vogelsang (2012) conducted an observational in Healthy (n=10). Hyperthermia (passive heating) vs. Baseline (thermoneutral) was evaluated on Correlation between changes in thorax/whole body blood pool ratio and arterial plasma ANP (R=0.80, p=<0.01). Hyperthermia-induced changes in central blood volume strongly correlated with changes in arterial plasma atrial natriuretic peptide (R=0.80, p<0.01), suggesting its utility as a surrogate marker.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: