Key result
ANP infusion increases urinary sodium excretion by ~25% in both hypertensive and normotensive subjects.
Why the study?
The physiological involvement of atrial natriuretic peptide (ANP) in body fluid volume regulation during sodium loading and ANP infusion was unclear.
Does dietary sodium loading and ANP infusion increase plasma ANP levels and urinary sodium excretion in normotensive and hypertensive individuals?
Comparison
High NaCl diet (20 g/day) and ANP infusion vs low NaCl diet (3 g/day) and baseline
Design
Physiological study with dietary intervention and graded ANP infusion
Authors
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ANP changes during salt loading are hypothesis-generating; leaves open any role in hypertension management.
Does dietary sodium loading and ANP infusion increase plasma ANP levels and urinary sodium excretion in normotensive and hypertensive individuals?
p-value: p=<0.02
A slight increase in plasma ANP induced by dietary sodium loading augments renal sodium excretion, suggesting ANP plays a physiological role in body fluid volume regulation.
Fukui et al. (1988) studied Hypertension and normal blood pressure (n=29). NaCl loading and ANP infusion vs. Low NaCl diet (3 g/day) and baseline was evaluated on Urinary Na excretion (p=<0.02). ANP infusion at 2.5 ng/kg/min increased urinary sodium excretion by 25% (P<0.02) in both hypertensive and normotensive subjects, suggesting a physiological role in body fluid volume regulation.
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