Key result
High NaCl diet raises plasma ANP ~60%, suggesting ANP regulates body fluid volume via Na excretion.
Why the study?
The physiological involvement of atrial natriuretic peptide in body fluid volume regulation during sodium loading and ANP infusion was unclear.
Does dietary NaCl loading and ANP infusion affect plasma ANP levels and urinary Na excretion in normotensive and hypertensive individuals?
Comparison
High NaCl diet (20 g/day) vs low NaCl diet (3 g/day) and graded ANP infusion vs baseline
Design
Physiological study with dietary intervention and ANP infusion
Authors
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Supports physiologic role of ANP in volume regulation; hypothesis-generating and should not change practice.
Does dietary NaCl loading and ANP infusion affect plasma ANP levels and urinary Na excretion in normotensive and hypertensive individuals?
p-value: p=<0.01
A slight increase in plasma ANP induced by dietary Na loading augments renal Na excretion, suggesting a physiological role for ANP in body fluid volume regulation.
Hirata et al. (1989) studied Normotension and Hypertension (n=29). NaCl loading and ANP infusion vs. Low NaCl diet / Baseline was evaluated on Plasma ANP level and urinary Na excretion (p=<0.01). High NaCl diet increased plasma ANP by 60% (p<0.01), and low-dose ANP infusion increased urinary Na excretion by 25% (p<0.02), suggesting ANP regulates body fluid volume.
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