Key result
Early after coronary artery bypass surgery, high plasma ADH concentrations in patients requiring IABP directly reflected hemodynamic derangement, while later secretion was influenced by surgical stress.
Why the study?
How do postoperative plasma antidiuretic hormone (ADH) concentrations correlate with hemodynamic parameters in patients undergoing coronary artery bypass surgery?
Observational (n=23)
How do postoperative plasma antidiuretic hormone (ADH) concentrations correlate with hemodynamic parameters in patients undergoing coronary artery bypass surgery?
Answers are grounded in this paper and cite their sources.
High plasma ADH concentrations early after CABG reflect hemodynamic derangement in patients requiring IABP, whereas later ADH secretion is likely driven by postsurgical stress.
In order to evaluate correlations in changes of postoperative plasma antidiuretic hormone (ADH) concentrations and hemodynamic parameters, 23 patients undergoing coronary artery bypass surgery were observed. 6 patients required intraaortic balloon pumping (IABP) (group I), 8 patients did not require IABP or inotropic agent (group II), and 9 patients required inotropic agent (group III) for weaning from cardiopulmonary bypass (CPB). Soon after CPB mean arterial and pulse pressures were significantly less in group I compared to other groups. Plasma ADH concentrations were significantly higher in group I than in group II, and showed significant negative correlation with hemodynamic parameters. On the 2nd postoperative day, plasma ADH concentrations in group I were significantly higher than in the other two groups, but were not correlated with hemodynamic parameters. Thus, early after surgery high plasma ADH concentrations in the IABP group directly reflected hemodynamic derangement, while at later times ADH secretion was influenced mainly by postsurgical stress.
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Amano et al. (1993) conducted an observational in Coronary artery bypass surgery (n=23). Requirement of intraaortic balloon pumping (IABP) or inotropic agents vs. No requirement of IABP or inotropic agents was evaluated on Correlations in changes of postoperative plasma antidiuretic hormone (ADH) concentrations and hemodynamic parameters. Early after coronary artery bypass surgery, high plasma ADH concentrations in patients requiring IABP directly reflected hemodynamic derangement, while later secretion was influenced by surgical stress.
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