Key result
A T cell clone (FA46) stimulated by T. cruzi B13 protein recognized both B13 (stimulation index 25.7) and human cardiac myosin, demonstrating molecular mimicry at the T cell level.
Population
T cell clones generated from a B13-stimulated T cell line obtained from peripheral blood of a B13-responsive…
Design
Preclinical
Authors
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Supports T-cell cross-reactivity in Chagas cardiomyopathy; hypothesis-generating and requires human confirmation before clinical relevance.
Effect estimate: SI = 25.7
Sensitization of T cells with T. cruzi B13 protein results in cross-reactivity to cardiac myosin, supporting the molecular mimicry hypothesis in the pathogenesis of chronic Chagas' disease cardiomyopathy.
Abel et al. (1997) studied Chagas' disease cardiomyopathy (n=1). T. cruzi B13 protein stimulation was evaluated on Proliferation against B13 protein and human cardiac myosin (SI = 25.7). A T cell clone (FA46) stimulated by T. cruzi B13 protein recognized both B13 (stimulation index 25.7) and human cardiac myosin, demonstrating molecular mimicry at the T cell level.
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