Why the study?
Prior studies showed LGE by CMR detects focal fibrosis in AS, but whether it predicts post-operative survival in severe AS undergoing AVR remained to be evaluated.
Population
154 consecutive surgical AVR and 40 TAVR patients with severe AS
Comparison
Presence vs absence of LGE by CMR
Design
Prospective cohort study
Follow-up
Median 2.9 years
Key result
The presence of late gadolinium enhancement by CMR was an independent predictor of all-cause mortality after surgical aortic valve replacement (HR 2.8; 95% CI 1.3-6.9; p=0.025).
Authors
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Observational study reveals late gadolinium enhancement on cardiac MRI predicts mortality after aortic valve replacement, indicating risk stratification utility.
Cohort (n=194)
Hazard Ratio: 2.8 (95% CI 1.3–6.9)
Absolute Event Rate: 73% vs 88%
p-value: p=0.025
Barone‐Rochette et al. (2014) conducted a cohort in Severe aortic stenosis (n=194). Late gadolinium enhancement (LGE) by CMR vs. Absence of LGE was evaluated on All-cause survival at 5 years (Kaplan-Meier estimates) and all-cause mortality after surgical AVR (HR 2.8, 95% CI 1.3-6.9, p=0.025). The presence of late gadolinium enhancement by CMR was an independent predictor of all-cause mortality after surgical aortic valve replacement (HR 2.8; 95% CI 1.3-6.9; p=0.025).
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