Key result
Baroreceptor sensitivity is significantly impaired in children after heart or heart-lung transplantation at rest and during tilting, with minimal recovery observed after 4 years post-transplantation.
Why the study?
Is baroreceptor sensitivity impaired in children after heart or heart-lung transplantation compared to healthy controls and non-cardiac transplant recipients?
Population
17 children who underwent heart or heart-lung transplantation, evaluated 6.1 +/- 3.7 years post-transplant.
Design
Cross-sectional
Authors
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May contribute to systolic hypertension in pediatric transplant recipients; hypothesis-generating for autonomic recovery interventions.
Observational (n=39)
Is baroreceptor sensitivity impaired in children after heart or heart-lung transplantation compared to healthy controls and non-cardiac transplant recipients?
Baroreceptor sensitivity is impaired in children following heart or heart-lung transplantation, with minimal recovery occurring more than four years post-transplant, potentially contributing to systolic hypertension.
Pozza et al. (2006) conducted an observational in Heart and heart-lung transplantation (n=39). Heart and heart-lung transplantation vs. Healthy children and children after liver/bone marrow transplantation taking cyclosporine A was evaluated on Baroreceptor sensitivity (BRS). Baroreceptor sensitivity is significantly impaired in children after heart or heart-lung transplantation at rest and during tilting, with minimal recovery observed after 4 years post-transplantation.
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