Key result
H-FABP demonstrated greater sensitivity, specificity, and ROC area under curve compared to CK-MB and myoglobin for the diagnosis of AMI within 6 hours of symptom onset.
Why the study?
Does H-FABP measurement improve the early diagnosis of AMI compared to CK-MB and myoglobin in patients with suspected AMI within 6 hours of symptom onset?
Population
80 subjects including 40 acute myocardial infarction cases and 40 non-cardiac chest pain otherwise healthy…
Comparison
Serum heart-type fatty acid binding protein… vs Serum CK-MB and myoglobin measurement
Design
Case-control
Authors
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May aid early AMI diagnosis; hypothesis-generating in case-control data, needs prospective validation.
Case-Control (n=80)
Does H-FABP measurement improve the early diagnosis of AMI compared to CK-MB and myoglobin in patients with suspected AMI within 6 hours of symptom onset?
H-FABP is a superior biomarker to CK-MB and myoglobin for the early diagnosis of acute myocardial infarction within 6 hours of symptom onset.
Anand K Pyati (2015) conducted a case-control in Acute Myocardial Infarction (n=80). Heart-type fatty acid binding protein (H-FABP) vs. CK-MB and myoglobin was evaluated on Diagnostic validity (sensitivity, specificity, PPV, NPV, and ROC curve analysis). H-FABP demonstrated greater sensitivity, specificity, and ROC area under curve compared to CK-MB and myoglobin for the diagnosis of AMI within 6 hours of symptom onset.
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