Key result
Graft rejection in pediatric heart transplant recipients was associated with a significant decline in left ventricular circumferential strain compared to an improvement in those without rejection (p=.02).
Why the study?
Surveillance protocols rely heavily on endomyocardial biopsy to detect rejection in pediatric heart transplant recipients, and more sensitive echocardiographic tools are needed to help limit biopsies.
Does change in left ventricular circumferential strain differentiate pediatric heart transplant recipients with and without graft rejection?
Comparison
Patients with graft rejection vs patients without graft rejection
Design
Single-center retrospective review
Authors
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Worsening circumferential strain was associated with rejection; hypothesis-generating for strain monitoring to potentially reduce biopsies in pediatric heart transplant recipients.
Cohort (n=34)
No
Does change in left ventricular circumferential strain differentiate pediatric heart transplant recipients with and without graft rejection?
p-value: p=.02
Worsening of left ventricular circumferential strain on echocardiography may help identify acute graft rejection in pediatric heart transplant recipients, potentially reducing the need for routine endomyocardial biopsies.
Boucek et al. (2021) conducted a cohort in Pediatric heart transplant recipients (n=34). Graft rejection vs. No graft rejection was evaluated on Change in left ventricular circumferential strain (p=.02). Graft rejection in pediatric heart transplant recipients was associated with a significant decline in left ventricular circumferential strain compared to an improvement in those without rejection (p=.02).
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