Key result
Decreased GCS is linked to severe acute allograft rejection with a 0.77 AUC for detection.
Why the study?
Noninvasive diagnosis of allograft rejection in heart transplant recipients with preserved LVEF is challenging and requires evaluation of new diagnostic tools.
Does 2-dimensional speckle-tracking echocardiography predict severe allograft rejection in adult heart transplant patients with preserved LVEF?
Population
65 adult heart transplant patients with preserved LVEF (> 55%) at Mayo Clinic
Comparison
Severe rejection by biopsy (Grade ≥ 2R) vs no rejection controls
Design
Retrospective case-control study with masked reviewers
Follow-up
Echocardiography within 1 month of biopsy
Authors
Loading...
GCS reduction was associated with severe rejection despite preserved LVEF; leaves open whether 2D-STE can safely reduce biopsy frequency.
Case-Control (n=65)
Masked to reviewers
No
Does 2-dimensional speckle-tracking echocardiography predict severe allograft rejection in adult heart transplant patients with preserved LVEF?
Effect estimate: AUC 0.77
Absolute Event Rate: -15.74% vs -19.9%
p-value: p=<0.001
2D-STE derived global circumferential strain may serve as a useful noninvasive tool to detect severe allograft rejection in heart transplant recipients with preserved LVEF.
Tseng et al. (2018) conducted a case-control in Heart transplant rejection (n=65). Severe acute allograft rejection vs. No rejection was evaluated on Global circumferential strain (GCS) (AUC 0.77, p=<0.001). Severe acute allograft rejection was associated with significantly decreased global circumferential strain (-15.74% vs -19.90%, p<0.001) and an AUC of 0.77 for detection in heart transplant patients with preserved ejection fraction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: