Key result
Post-operative DVT occurred in 1.2% of cancer patients receiving heparin prophylaxis versus 23.5% of those not receiving prophylaxis, while pre-operative TAT > 3.5 ng/ml identified high-risk patients.
Why the study?
Do pre-surgical plasma levels of TAT and F1+2 identify cancer patients at high risk of post-operative DVT, and does heparin prophylaxis modulate coagulation?
Population
117 cancer patients undergoing major surgery for localized tumours, and 50 age-matched control subjects.
Comparison
Heparin prophylaxis and biomarker assessment vs No heparin prophylaxis and age-matched controls
Design
Cohort
Follow-up
post-operative
Authors
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TAT may identify high-risk cancer surgery patients; leaves open whether TAT-guided prophylaxis improves DVT outcomes.
Observational (n=167)
Do pre-surgical plasma levels of TAT and F1+2 identify cancer patients at high risk of post-operative DVT, and does heparin prophylaxis modulate coagulation?
Absolute Event Rate: 1.2% vs 23.5%
Pre-operative TAT levels > 3.5 ng/ml may identify cancer patients at high risk for post-operative DVT, and heparin prophylaxis reduces post-operative DVT and modulates coagulation.
Falanga et al. (1993) conducted an observational in Cancer undergoing major surgery (n=167). Heparin prophylaxis vs. No heparin prophylaxis was evaluated on Post-operative DVT. Post-operative DVT occurred in 1.2% of cancer patients receiving heparin prophylaxis versus 23.5% of those not receiving prophylaxis, while pre-operative TAT > 3.5 ng/ml identified high-risk patients.
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