Key result
Crohn's disease patients with metabolic syndrome had an adjusted CD-related hospitalization rate twice that of patients without metabolic syndrome.
Why the study?
Does metabolic syndrome increase the rate of CD-related hospitalization in patients with Crohn's disease?
Cohort (n=868)
No
Does metabolic syndrome increase the rate of CD-related hospitalization in patients with Crohn's disease?
Crohn's disease patients with metabolic syndrome have a significantly higher rate of CD-related hospitalizations, suggesting metabolic components may serve as markers of inflammation.
Answers are grounded in this paper and cite their sources.
Metabolic syndrome was associated with higher CD hospitalization rates; leaves open whether metabolic interventions modify Crohn's outcomes.
BACKGROUND/AIMS: Recent studies suggest that markers of mesenteric inflammation, such as increased adipose tissue, may be associated with poor outcomes in Crohn's disease (CD). This study's hypothesis is that CD patients with metabolic syndrome (MetS) have more CD-related hospitalizations than CD patients without MetS. METHODS: We conducted a retrospective cohort study of CD patients seen from 2000 to 2012 at our tertiary care center. We analyzed crude and age-, sex- and duration of CD-adjusted incidence rate ratio (IRR) of CD-related hospitalization of those with MetS versus those without MetS. We also investigated possible associations between individual component conditions of MetS and rate of CD-related hospitalization. RESULTS: A total of 868 CD patients were included. There were 37 (4%) patients with MetS at initial observation. After multi-variable adjustment, patients with MetS had a CD-related hospitalization rate twice that of those who did not have MetS. High triglycerides (TG), low high density lipoprotein (HDL) cholesterol and diabetes mellitus (DM) were associated with increased risk of CD-related hospitalization. CONCLUSIONS: CD patients with MetS have a higher rate of CD-related hospitalization compared to those without MetS. Hypertriglyceridemia, low HDL cholesterol and DM may be good markers of local and systemic inflammation as seen in CD.
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Fitzmorris et al. (2015) conducted a cohort in Crohn's disease (n=868). Metabolic syndrome vs. No metabolic syndrome was evaluated on CD-related hospitalization rate (IRR 2.0). Crohn's disease patients with metabolic syndrome had an adjusted CD-related hospitalization rate twice that of patients without metabolic syndrome.
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